Immunomodulators (TNF inhibitors)
- Neutralize TNF signaling
- Major drugs across RA, IBD, psoriasis + SpA
- Screen for TB + hepatitis B before therapy
- Serious infection risk is the main concern
- Can worsen demyelination/heart failure in some
- Antidrug antibodies affect some agents
Class at a glance
- Neutralize TNF signaling
Members / distinctions
- Major drugs across RA, IBD, psoriasis + SpA
- Screen for TB + hepatitis B before therapy
Practical pearls
- Can worsen demyelination/heart failure in some
- Antidrug antibodies affect some agents
Safety / monitoring
- Serious infection risk is the main concern
Pearls
- Considered safe in pregnancy and lactation; minimal milk transfer
- More pregnancy reassurance than IL-17 or IL-23 biologics
Self-check
- What infections should be screened for before TNF inhibitors?
TB and hepatitis B. - What is the main concern with TNF inhibitors?
Serious infection.
Drugs in this class (3)
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