Immunomodulators (JAK inhibitors)
- Oral inhibitors of JAK-STAT cytokine signaling
- Treat RA, dermatitis, IBD + other diseases
- Fast and potent but systemically immunomodulatory
- Serious infection/zoster risk is important
- Thrombosis/MACE/malignancy warnings matter
- Drug selectivity does not eliminate class risk
Class at a glance
- Oral inhibitors of JAK-STAT cytokine signaling
Clinical role
- Treat RA, dermatitis, IBD + other diseases
- Fast and potent but systemically immunomodulatory
Safety / monitoring
- Serious infection/zoster risk is important
Safety distinctions
- Thrombosis/MACE/malignancy warnings matter
- Drug selectivity does not eliminate class risk
Drugs in this class (6)
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