Immunomodulators (fumarates)
- Fumarate derivatives alter immune/redox signaling
- Dimethyl fumarate is a major example
- Used in MS; related drugs in psoriasis
- Flushing + GI effects are common
- Lymphopenia requires monitoring
- Rare PML risk rises with prolonged lymphopenia
Class at a glance
- Fumarate derivatives alter immune/redox signaling
Practical pearls
- Dimethyl fumarate is a major example
Safety / monitoring
- Used in MS; related drugs in psoriasis
- Flushing + GI effects are common
Safety distinctions
- Lymphopenia requires monitoring
- Rare PML risk rises with prolonged lymphopenia
Drugs in this class (2)
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