GnRH agonists
- Initial stimulation → later receptor downregulation
- Suppress gonadal sex-hormone production
- Prostate cancer, endometriosis, fibroids, puberty
- Early testosterone flare matters in prostate CA
- Hot flashes + bone loss with prolonged use
- Add-back therapy can reduce hypoestrogenic AEs
- Depot formulations are common
Class at a glance
- Initial stimulation → later receptor downregulation
Practical pearls
- Suppress gonadal sex-hormone production
Clinical role
- Prostate cancer, endometriosis, fibroids, puberty
- Early testosterone flare matters in prostate CA
Other clinical roles
- Hot flashes + bone loss with prolonged use
- Add-back therapy can reduce hypoestrogenic AEs
- Depot formulations are common
Self-check
- What is the main pharmacologic action of GnRH agonists?
Initial stimulation → later receptor downregulation.
Drugs in this class (2)
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