Gepants
- Small-molecule CGRP-pathway antagonists
- Acute migraine: ubrogepant/rimegepant/zavegepant
- Prevention: rimegepant/atogepant
- No vasoconstriction → useful if triptan unsuitable
- Generally nonsedating
- CYP3A/P-gp interactions matter for oral agents
- Medication-overuse signal appears lower than opioids
Class at a glance
- Small-molecule CGRP-pathway antagonists
Members / distinctions
- Prevention: rimegepant/atogepant
Pharmacology
- CYP3A/P-gp interactions matter for oral agents
Clinical role
- Acute migraine: ubrogepant/rimegepant/zavegepant
- No vasoconstriction → useful if triptan unsuitable
- Medication-overuse signal appears lower than opioids
Safety / monitoring
Drugs in this class (4)
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