Gabapentinoids
- Alpha-2-delta calcium-channel ligands
- Neuropathic pain; pregabalin also fibromyalgia
- Gabapentin/pregabalin also antiseizure drugs
- Sedation, dizziness, edema + weight gain
- Renally cleared → dose by kidney function
- Misuse occurs, especially with opioids
- Opioid combo ↑ respiratory-depression risk
Class at a glance
- Alpha-2-delta calcium-channel ligands
Clinical role
- Neuropathic pain; pregabalin also fibromyalgia
- Misuse occurs, especially with opioids
Safety / monitoring
- Gabapentin/pregabalin also antiseizure drugs
- Sedation, dizziness, edema + weight gain
Safety distinctions
- Renally cleared → dose by kidney function
- Opioid combo ↑ respiratory-depression risk
Self-check
- What is the main pharmacologic action of Gabapentinoids?
Alpha-2-delta calcium-channel ligands.
Drugs in this class (3)
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