Endothelin receptor antagonists
- Pulmonary arterial vasodilators
- Bosentan/ambrisentan/macitentan
- Improve exercise capacity/outcomes in PAH
- Edema, anemia + hypotension can occur
- Hepatotoxicity is most notable with bosentan
- Teratogenic → strict pregnancy precautions
- Often combined with PDE5/prostacyclin therapy
Class at a glance
- Pulmonary arterial vasodilators
Practical pearls
- Bosentan/ambrisentan/macitentan
Members / distinctions
- Improve exercise capacity/outcomes in PAH
- Often combined with PDE5/prostacyclin therapy
Safety / monitoring
- Edema, anemia + hypotension can occur
- Hepatotoxicity is most notable with bosentan
- Teratogenic → strict pregnancy precautions
Self-check
- Key risk with Endothelin receptor antagonists?
Edema, anemia + hypotension can occur. - Which endothelin antagonist has the most notable hepatotoxicity?
Bosentan.
Drugs in this class (5)
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