Dopamine reuptake inhibitors
- Wake-promoting drugs whose primary site is the dopamine transporter: modafinil and its R-enantiomer armodafinil
- Weak, slow DAT occupancy — alertness without the reinforcement of the amphetamines
- CYP3A4 inducers: oral contraceptive failure is the interaction to counsel on
- Schedule IV; serious rash (SJS) is the rare class warning
Class at a glance
- Wake-promoting drugs whose primary site is the dopamine transporter: modafinil and its R-enantiomer armodafinil
- Weak, slow DAT occupancy — alertness without the reinforcement of the amphetamines
Practical pearls
- CYP3A4 inducers: oral contraceptive failure is the interaction to counsel on
- Schedule IV; serious rash (SJS) is the rare class warning
Self-check
- Why does modafinil carry a contraception warning?
It induces CYP3A4 and lowers steroidal contraceptive exposure.
Drugs in this class (2)
All drug classes · Open Dopamine reuptake inhibitors in the interactive console ↗