Diuretics (potassium-sparing)
- Reduce distal nephron K+ loss
- ENaC blockers: amiloride/triamterene
- MRAs: spironolactone/eplerenone
- Often paired with kaliuretic diuretics
- Hyperkalemia is the key toxicity
- Amiloride uniquely treats lithium-induced NDI
- Renal function determines safety
Class at a glance
- Reduce distal nephron K+ loss
Members / distinctions
- MRAs: spironolactone/eplerenone
Pharmacology
- ENaC blockers: amiloride/triamterene
Clinical role
- Often paired with kaliuretic diuretics
- Amiloride uniquely treats lithium-induced NDI
Safety / monitoring
- Hyperkalemia is the key toxicity
- Renal function determines safety
Self-check
- What is the key toxicity of potassium-sparing diuretics?
Hyperkalemia. - Which potassium-sparing diuretic treats lithium-induced NDI?
Amiloride.
Drugs in this class (4)
Diuretics (potassium-sparing) prescription history
Animated chart of estimated U.S. prescriptions per year, Diuretics (1953–2026). Potassium sparing highlighted from 1960.
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