Diuretics (potassium-sparing)
- Reduce distal nephron K+ loss
- ENaC blockers: amiloride/triamterene
- MRAs: spironolactone/eplerenone
- Often paired with kaliuretic diuretics
- Hyperkalemia is the key toxicity
- Amiloride uniquely treats lithium-induced NDI
- Renal function determines safety
Class at a glance
- Reduce distal nephron K+ loss
Members / distinctions
- MRAs: spironolactone/eplerenone
Pharmacology
- ENaC blockers: amiloride/triamterene
Clinical role
- Often paired with kaliuretic diuretics
- Amiloride uniquely treats lithium-induced NDI
Safety / monitoring
- Hyperkalemia is the key toxicity
- Renal function determines safety
Self-check
- What do Diuretics (potassium-sparing) primarily reduce?
distal nephron K+ loss.
Drugs in this class (4)
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