COMT inhibitors
- Prolong levodopa effect by blocking COMT
- Parkinson motor fluctuations/OFF time
- Entacapone: with each levodopa dose
- Opicapone: once daily
- Tolcapone: effective but liver-toxicity burden
- Can worsen dyskinesia as levodopa rises
- Reduce levodopa dose if needed
Class at a glance
- Prolong levodopa effect by blocking COMT
Members / distinctions
- Entacapone: with each levodopa dose
Safety / monitoring
- Opicapone: once daily
- Tolcapone: effective but liver-toxicity burden
Other member distinctions
- Parkinson motor fluctuations/OFF time
- Can worsen dyskinesia as levodopa rises
- Reduce levodopa dose if needed
Self-check
- What do COMT inhibitors primarily reduce?
levodopa dose if needed.
Drugs in this class (3)
All drug classes · Open the interactive console ↗
