Chelators (iron)
- Bind excess iron for excretion
- Deferasirox: oral, once daily
- Deferiprone: oral; agranulocytosis monitoring
- Deferoxamine: parenteral; burdensome but effective
- Used for transfusional/chronic iron overload
- Renal/hepatic toxicity varies by agent
- Choice depends on iron burden + organ disease
Class at a glance
- Bind excess iron for excretion
Safety / monitoring
- Deferasirox: oral, once daily
- Deferiprone: oral; agranulocytosis monitoring
- Deferoxamine: parenteral; burdensome but effective
Clinical role
- Used for transfusional/chronic iron overload
- Choice depends on iron burden + organ disease
Safety distinctions
- Renal/hepatic toxicity varies by agent
Self-check
- What are Chelators (iron) used for?
transfusional/chronic iron overload.
- What do Chelators (iron) bind?
excess iron for excretion.
Drugs in this class (3)
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