Cephalosporins (second-generation)
- Broader Gram-negative activity than first-gen
- Cefuroxime is a common example
- Cephamycins add anaerobic activity
- cefoxitin/cefotetan
- Uses vary more than the generation label
- Generation is a rough—not absolute—spectrum map
Class at a glance
- Broader Gram-negative activity than first-gen
Practical pearls
- Cefuroxime is a common example
Other practical pearls
- Cephamycins add anaerobic activity
- cefoxitin/cefotetan
Clinical role
- Uses vary more than the generation label
- Generation is a rough—not absolute—spectrum map
Self-check
- What coverage do cephamycins add?
Anaerobic activity. - Is cephalosporin generation an absolute spectrum map?
No; only a rough map.
Drugs in this class (2)
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