Bisphosphonates
- Suppress osteoclast-mediated bone resorption
- First-line osteoporosis drugs for many patients
- Alendronate/risedronate oral; zoledronate IV
- ↓ vertebral and hip fracture risk
- Oral drugs can irritate esophagus
- Rare ONJ + atypical femur fracture
- Long-term need → consider drug-holiday strategy
Class at a glance
- Suppress osteoclast-mediated bone resorption
Members / distinctions
- Alendronate/risedronate oral; zoledronate IV
- Oral drugs can irritate esophagus
Other member distinctions
- Rare ONJ + atypical femur fracture
- Long-term need → consider drug-holiday strategy
Safety / monitoring
- First-line osteoporosis drugs for many patients
- ↓ vertebral and hip fracture risk
Self-check
- Which drug class is first-line for osteoporosis drugs for many patients?
Bisphosphonates.
Drugs in this class (5)
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