Antivirals (HCV NS5A inhibitors)
- Block HCV NS5A replication/assembly
- “-asvir” drugs
- Very potent; always part of combinations
- Resistance can matter after prior failure
- DDI profiles vary by partner regimen
- Core component of modern curative HCV therapy
Class at a glance
- Block HCV NS5A replication/assembly
Practical pearls
- “-asvir” drugs
- Very potent; always part of combinations
Other practical pearls
- Resistance can matter after prior failure
Clinical pearls
- DDI profiles vary by partner regimen
- Core component of modern curative HCV therapy
Self-check
- When can resistance especially matter for HCV NS5A inhibitors?
After prior treatment failure. - What suffix identifies HCV NS5A inhibitors?
“-asvir”.
Drugs in this class (4)
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