Antivirals (HCV NS3/4A protease inhibitors)
- Block HCV NS3/4A viral protease
- “-previr” drugs
- Always used in combination regimens
- Major CYP/transporter DDIs are common
- Avoid many regimens in decompensated cirrhosis
- Modern courses can cure HCV
Class at a glance
- Block HCV NS3/4A viral protease
Practical pearls
- Modern courses can cure HCV
Pharmacology
- Major CYP/transporter DDIs are common
Clinical role
- “-previr” drugs
- Always used in combination regimens
Safety / monitoring
- Avoid many regimens in decompensated cirrhosis
Self-check
- Are HCV NS3/4A protease inhibitors used alone?
No; always in combination regimens. - In which liver condition should many HCV protease-inhibitor regimens be avoided?
Decompensated cirrhosis.
Drugs in this class (2)
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