Antiseizure medications (ASMs, SV2A ligands)
- Bind synaptic vesicle protein SV2A
- Levetiracetam/brivaracetam prototypes
- Broad antiseizure utility
- Few CYP interactions
- Somnolence/dizziness are common
- Irritability/behavioral effects can be limiting
Class at a glance
- Bind synaptic vesicle protein SV2A
Practical pearls
- Levetiracetam/brivaracetam prototypes
Pharmacology
- Few CYP interactions
Members / distinctions
- Somnolence/dizziness are common
- Irritability/behavioral effects can be limiting
Other practical pearls
- Broad antiseizure utility
Self-check
- What can limit tolerability of SV2A ligands?
Irritability and behavioral effects. - Which drugs are SV2A-ligand prototypes?
Levetiracetam and brivaracetam.
Drugs in this class (2)
Antiseizure medications (ASMs, SV2A ligands) prescription history
Animated chart of estimated U.S. prescriptions per year, Antiseizure meds (1869–2026). SV2A ligands highlighted from 2000.
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