Antineoplastics (immune checkpoint inhibitors / ICIs)
- Release T-cell inhibition against cancer
- PD-1/PD-L1 and CTLA-4 are major targets
- Can produce durable responses across tumors
- Toxicity = autoimmune inflammation
- skin, gut, lung, liver, endocrine organs
- Steroids treat many significant immune AEs
- Effects/toxicity can persist after drug stops
Class at a glance
- Release T-cell inhibition against cancer
Practical pearls
- PD-1/PD-L1 and CTLA-4 are major targets
Clinical role
- Can produce durable responses across tumors
- Steroids treat many significant immune AEs
Safety / monitoring
- Toxicity = autoimmune inflammation
- skin, gut, lung, liver, endocrine organs
- Effects/toxicity can persist after drug stops
Drugs in this class (2)
All drug classes · Open the interactive console ↗
