Antineoplastics (HDAC inhibitors)
- Inhibit histone deacetylases
- Alter chromatin + gene expression
- Mainly used in selected hematologic cancers
- Cytopenias, fatigue + GI effects are common
- QT and infection issues vary by agent
- Usually specialist later-line therapy
Class at a glance
- Inhibit histone deacetylases
Clinical role
- Alter chromatin + gene expression
- Mainly used in selected hematologic cancers
Safety / monitoring
- Cytopenias, fatigue + GI effects are common
- Usually specialist later-line therapy
Safety distinctions
- QT and infection issues vary by agent
Self-check
- What is the main pharmacologic action of Antineoplastics (HDAC inhibitors)?
Inhibit histone deacetylases.
- What key adverse effect/risk occurs with Antineoplastics (HDAC inhibitors)?
QT and infection issues vary by agent.
Drugs in this class (5)
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