Antineoplastics (antimetabolites)
- Mimic/block nucleotides or folate pathways
- Disrupt DNA/RNA synthesis
- Includes methotrexate, 5-FU, cytarabine
- Myelosuppression + mucositis are common
- Organ-specific toxicities differ sharply
- Rescue/antidote strategies exist for some
Class at a glance
- Mimic/block nucleotides or folate pathways
Practical pearls
- Includes methotrexate, 5-FU, cytarabine
Pharmacology
- Disrupt DNA/RNA synthesis
Other practical pearls
- Rescue/antidote strategies exist for some
Members / distinctions
- Myelosuppression + mucositis are common
- Organ-specific toxicities differ sharply
Self-check
- Which major drug groups are included in Antineoplastics (antimetabolites)?
methotrexate, 5-FU, cytarabine.
- What is the main pharmacologic action of Antineoplastics (antimetabolites)?
Mimic/block nucleotides or folate pathways.
Drugs in this class (5)
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