Antineoplastics (alkylating)
- Covalently damage/crosslink DNA
- Cell-cycle nonspecific cytotoxic therapy
- Includes cyclophosphamide/ifosfamide
- Myelosuppression is common
- Gonadal + secondary-cancer risk can matter
- Some have distinctive organ toxicities
Class at a glance
- Covalently damage/crosslink DNA
Practical pearls
- Includes cyclophosphamide/ifosfamide
Members / distinctions
- Cell-cycle nonspecific cytotoxic therapy
- Myelosuppression is common
Safety / monitoring
- Gonadal + secondary-cancer risk can matter
- Some have distinctive organ toxicities
Self-check
- Which groups are included in Antineoplastics (alkylating)?
Cyclophosphamide/ifosfamide. - How does Antineoplastics (alkylating) work?
Covalently damage/crosslink DNA.
Drugs in this class (3)
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