Antihyperglycemics (DPP-4 inhibitors)
- Modest oral glucose-lowering drugs
- Weight-neutral; very low hypoglycemia
- Sitagliptin/linagliptin common
- Linagliptin needs no renal dose adjustment
- Less potent than GLP-1/SGLT2 therapies
- Saxagliptin: HF hospitalization concern
- Do not routinely combine with GLP-1 drugs
Class at a glance
- Modest oral glucose-lowering drugs
Members / distinctions
- Less potent than GLP-1/SGLT2 therapies
- Saxagliptin: HF hospitalization concern
Practical pearls
- Sitagliptin/linagliptin common
- Do not routinely combine with GLP-1 drugs
Other member distinctions
- Weight-neutral; very low hypoglycemia
- Linagliptin needs no renal dose adjustment
Self-check
- Should Antihyperglycemics (DPP-4 inhibitors) routinely be combined with GLP-1 drugs?
No.
Drugs in this class (4)
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