Antidepressants (SARIs)
- 5-HT2 antagonism + weak/moderate SRI
- Trazodone/nefazodone are prototypes
- Trazodone: depression drug, often used for sleep
- Sedation + orthostasis are prominent
- Trazodone: rare priapism
- Nefazodone: severe hepatotoxicity risk
- Not interchangeable with standard SSRIs
Class at a glance
- 5-HT2 antagonism + weak/moderate SRI
Members / distinctions
- Trazodone/nefazodone are prototypes
- Trazodone: rare priapism
Clinical role
- Trazodone: depression drug, often used for sleep
- Not interchangeable with standard SSRIs
Safety / monitoring
- Sedation + orthostasis are prominent
- Nefazodone: severe hepatotoxicity risk
Self-check
- What is trazodone used for?
Depression; often sleep.
Drugs in this class (2)
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