Antidepressants (SARIs)
- 5-HT2 antagonism + weak/moderate SRI
- Trazodone/nefazodone are prototypes
- Trazodone: depression drug, often used for sleep
- Sedation + orthostasis are prominent
- Trazodone: rare priapism
- Nefazodone: severe hepatotoxicity risk
- Not interchangeable with standard SSRIs
Class at a glance
- 5-HT2 antagonism + weak/moderate SRI
Members / distinctions
- Trazodone/nefazodone are prototypes
- Trazodone: rare priapism
Clinical role
- Trazodone: depression drug, often used for sleep
- Not interchangeable with standard SSRIs
Safety / monitoring
- Sedation + orthostasis are prominent
- Nefazodone: severe hepatotoxicity risk
Self-check
- What is trazodone used for?
Depression; often sleep. - What rare adverse effect is associated with trazodone?
Priapism.
Drugs in this class (2)
Antidepressants (SARIs) prescription history
Animated chart of estimated U.S. prescriptions per year, Antidepressants (1957–2026). SARI highlighted from 1981.
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