Antidepressants (multimodal serotonergic)
- Combine SERT blockade with 5-HT receptor effects
- Vortioxetine/vilazodone are main examples
- Used for major depression
- Nausea is common early
- Sexual AEs still occur; may be less with vortioxetine
- Vilazodone must be taken with food
- Both remain serotonergic MAOI hazards
Class at a glance
- Combine SERT blockade with 5-HT receptor effects
Practical pearls
- Vortioxetine/vilazodone are main examples
Members / distinctions
- Sexual AEs still occur; may be less with vortioxetine
- Both remain serotonergic MAOI hazards
Clinical role
- Used for major depression
- Nausea is common early
- Vilazodone must be taken with food
Self-check
- What are Antidepressants (multimodal serotonergic) used for?
Major depression. - How does Antidepressants (multimodal serotonergic) work?
Combine SERT blockade with 5-HT receptor effects.
Drugs in this class (3)
Antidepressants (multimodal serotonergic) prescription history
Animated chart of estimated U.S. prescriptions per year, Antidepressants (1957–2026).
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