Antidepressants (multimodal serotonergic)
- Combine SERT blockade with 5-HT receptor effects
- Vortioxetine/vilazodone are main examples
- Used for major depression
- Nausea is common early
- Sexual AEs still occur; may be less with vortioxetine
- Vilazodone must be taken with food
- Both remain serotonergic MAOI hazards
Class at a glance
- Combine SERT blockade with 5-HT receptor effects
Practical pearls
- Vortioxetine/vilazodone are main examples
Members / distinctions
- Sexual AEs still occur; may be less with vortioxetine
- Both remain serotonergic MAOI hazards
Clinical role
- Used for major depression
- Nausea is common early
- Vilazodone must be taken with food
Self-check
- What are Antidepressants (multimodal serotonergic) used for?
major depression.
- What is the main pharmacologic action of Antidepressants (multimodal serotonergic)?
Combine SERT blockade with 5-HT receptor effects.
Drugs in this class (3)
All drug classes · Open the interactive console ↗
