Antidepressants (MAOIs)
- Highly effective but interaction-heavy
- Best-known role: resistant/atypical MDD
- Tranylcypromine/phenelzine most familiar
- Irreversible MAO blockade persists after stop
- Tyramine → hypertensive crisis risk
- Potent SRIs/releasers → fatal ST risk
- Treatment requires deliberate washouts
Class at a glance
- Highly effective but interaction-heavy
Pharmacology
- Tranylcypromine/phenelzine most familiar
- Irreversible MAO blockade persists after stop
Clinical role
- Best-known role: resistant/atypical MDD
- Treatment requires deliberate washouts
Safety / monitoring
- Tyramine → hypertensive crisis risk
- Potent SRIs/releasers → fatal ST risk
Drugs in this class (4)
All drug classes · Open the interactive console ↗
