Anticoagulant reversal agents

Reverse or bypass anticoagulant effect
Vitamin K/PCC: warfarin
Idarucizumab: dabigatran
Andexanet: selected factor Xa inhibitors
Protamine: heparin > LMWH
Reversal choice depends on bleeding severity

Class at a glance

Reverse or bypass anticoagulant effect

Pharmacology

Idarucizumab: dabigatran
Andexanet: selected factor Xa inhibitors
Protamine: heparin > LMWH

Members / distinctions

Vitamin K/PCC: warfarin

Safety / monitoring

Reversal choice depends on bleeding severity

Self-check

Which anticoagulant does idarucizumab reverse?
Dabigatran.
What determines anticoagulant reversal choice?
Bleeding severity.

Drugs in this class (4)

Andexanet alfa ballicule — decagon mechanism diagram — Andexanet alfa

Idarucizumab ballicule — decagon mechanism diagram — Idarucizumab

Protamine sulfate ballicule — decagon mechanism diagram — Protamine sulfate

Phytonadione ballicule — decagon mechanism diagram — Phytonadione

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