Antiarrhythmics (Vaughan-Williams IV)
- Non-DHP Ca2+ channel blockers
- Verapamil + diltiazem slow AV nodal conduction
- Useful for SVT and AF rate control
- Can cause bradycardia + hypotension
- Avoid in significant HFrEF
- CYP/P-gp interactions are clinically important
Class at a glance
- Non-DHP Ca2+ channel blockers
Pharmacology
- CYP/P-gp interactions are clinically important
Clinical role
- Verapamil + diltiazem slow AV nodal conduction
- Useful for SVT and AF rate control
Safety / monitoring
- Can cause bradycardia + hypotension
- Avoid in significant HFrEF
Self-check
- When are Antiarrhythmics (Vaughan-Williams IV) especially useful?
SVT and AF rate control. - When should Antiarrhythmics (Vaughan-Williams IV) generally be avoided?
Significant HFrEF.
Drugs in this class (2)
Antiarrhythmics (Vaughan-Williams IV) prescription history
Animated chart of estimated U.S. prescriptions per year, Calcium-channel blockers (1981–2026). Non-dihydropyridine highlighted from 1981.
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