Androgen receptor antagonists
- Block androgen-receptor signaling
- Major use: prostate cancer
- Enzalutamide/apalutamide are potent AR blockers
- Bicalutamide is an older antiandrogen
- Can cause fatigue, falls + sexual effects
- Usually paired with androgen deprivation
Class at a glance
- Block androgen-receptor signaling
Practical pearls
- Bicalutamide is an older antiandrogen
Pharmacology
- Enzalutamide/apalutamide are potent AR blockers
Clinical role
- Major use: prostate cancer
- Usually paired with androgen deprivation
Other practical pearls
- Can cause fatigue, falls + sexual effects
Self-check
- What is the major clinical use of androgen-receptor antagonists?
Prostate cancer.
- What is their main pharmacologic action?
Block androgen-receptor signaling.
Drugs in this class (3)
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