Aminoglycosides
- Rapid bactericidal 30S inhibitors
- Best for serious aerobic gram-negative disease
- Often combined for empiric/severe infection
- Poor oral absorption → usually IV/IM
- Nephrotoxicity + ototoxicity are major risks
- Neuromuscular blockade can occur
- Drug levels/renal dosing often matter
Class at a glance
- Rapid bactericidal 30S inhibitors
Pharmacology
- Neuromuscular blockade can occur
Members / distinctions
- Best for serious aerobic gram-negative disease
- Poor oral absorption → usually IV/IM
Safety / monitoring
- Often combined for empiric/severe infection
- Nephrotoxicity + ototoxicity are major risks
- Drug levels/renal dosing often matter
Self-check
- What are the major aminoglycoside toxicities?
Nephrotoxicity and ototoxicity. - Why are aminoglycosides usually given IV/IM?
Poor oral absorption.
Drugs in this class (4)
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